Peptide Database

Peptide NamePhylloseptin-SP1 (PLS-SP1)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity

Standard StatusStandard

Sequence Length68 amino acids

Chemical FormulaC348H563N91O107S2

DescriptionStandard

        MAFLKKSLFLVLFLGLVSLSICEEKERETKEEENEQEDDNREEKRFLSLIPHVISAIPHVVNALSNLG
    

Molecular Weight7797.87 Da

Isoelectric Point (pI)4.90

Net Charge (pH 7.0)-5.31

Net Charge (pH 7.4) -5.67

Charge Density (pH 7.0) -0.0780

GRAVY Index-0.15

Hydrophobic Moment 0.68

Boman Index0.01

Instability Index42.04

Aliphatic Index 111.76

Aromaticity 0.0588

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3210.56

LogP -26.23

H-bond Donors 109.0

H-bond Acceptors 106.0

Rotatable Bonds 271.0

Heavy Atoms 548.0

Ring Count 8.0

Amide Bonds 72.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0008291 VERIFIED: YES

Provenance & Taxonomy

OrganismAgalychnis spurrelli [Animal]

FamilyPhylloseptin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic

TargetStaphylococcus aureus (Gram-positive)

RECORD: Rec_0155204 VERIFIED: YES

Provenance & Taxonomy

OrganismAgalychnis spurrelli [Animal]

FamilyPhylloseptin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic

TargetCandida albicans

RECORD: Rec_0171636 VERIFIED: NO

Provenance & Taxonomy

OrganismAgalychnis spurrelli [Animal]

FamilyPhylloseptin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial

RECORD: Rec_0177261 VERIFIED: YES

Provenance & Taxonomy

OrganismAgalychnis spurrelli [Animal]

FamilyPhylloseptin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic

TargetEscherichia coli (Gram-negative)

RECORD: Rec_0393318 VERIFIED: YES

Provenance & Taxonomy

OrganismAgalychnis spurrelli [Animal]

FamilyPhylloseptin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic

TargetK. pneumoniae (Gram-negative)