Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length138 amino acids

Chemical FormulaC706H1073N159O207S6

DescriptionStandard

        GIVYPAGNYTGPPYVATPFAIPDQNDSMLYLAFSEYFFQTSLFSYYTAGAFNITIAKEIAKYPIIPYPVMMKLMATEIPLVSLQQDSFTLEIQESMEVFALLPDSTTQSLFTVNVAANTSIALNVFDQKLTGSLCLNR
    

Molecular Weight15292.40 Da

Isoelectric Point (pI)4.22

Net Charge (pH 7.0)-6.24

Net Charge (pH 7.4) -6.49

Charge Density (pH 7.0) -0.0452

GRAVY Index0.29

Hydrophobic Moment 0.51

Boman Index0.26

Instability Index39.36

Aliphatic Index 94.06

Aromaticity 0.1377

Extinction Coeff. Reduced 13410.00

Extinction Coeff. Oxidized 13410.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 5789.02

LogP -47.88

H-bond Donors 194.0

H-bond Acceptors 207.0

Rotatable Bonds 481.0

Heavy Atoms 1078.0

Ring Count 29.0

Amide Bonds 151.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0092433 VERIFIED: NO

Provenance & Taxonomy

OrganismBambusicola thoracicus [Plant]

FamilyBPI

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence