Peptide Database

Peptide NameSLAY-screened peptide P1596

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC109H166N30O30S2

DescriptionStandard

        PWVYRCVRPLNYPIASSTTCN
    

Molecular Weight2440.80 Da

Isoelectric Point (pI)9.00

Net Charge (pH 7.0)1.94

Net Charge (pH 7.4) 1.85

Charge Density (pH 7.0) 0.0922

GRAVY Index-0.18

Hydrophobic Moment 0.65

Boman Index0.02

Instability Index13.10

Aliphatic Index 69.52

Aromaticity 0.1429

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8605.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 960.90

LogP -9.54

H-bond Donors 37.0

H-bond Acceptors 34.0

Rotatable Bonds 69.0

Heavy Atoms 171.0

Ring Count 7.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0425108 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/