Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length473 amino acids

Chemical FormulaC2345H3801N611O649S18

DescriptionStandard

        MFPWRWLALLALIPLSLSANAGVKVKLTQKGLDFGRELAVASLQKKLMTIKVPDISGKERVKPIGKVRYSVTEMRVVKLGLPSSAIGLVPGTGFSLTITNAFLSLHGRWRVKYLRFIKDRGSFDLAIKSLSITTSISLRSDNMGLPAVAMASCTTTLGGVSVKLHGGASWLYNLFRRFIEKGLQSQLQKKLCPLVAESVSSMNQFLKTVNVMAPVDRYAEIAYPMVSSPDISSSSIGLNLKGEFYNIGNHMEPPFSPAPFFLPNQEQSMLYIGLSAFTANSASFVYNKAGTLSLKITDDMVPRSSPIRLTTNTFGVLIPQIAKLFPGLMMVLQLKMTKDPLSSIEANKVTVDAKSSLTAYAILANTKLAPLFVLNLDFSVSARVNVVGNKLAGAVTLNRLDMSLGKSYVGDFKVGSLSNIFQIVLKWVVLPTVNVRLKEGFPLPSLGKINLKNTQLQILKGYIMIGTDLQNSG
    

Molecular Weight51515.14 Da

Isoelectric Point (pI)10.04

Net Charge (pH 7.0)26.74

Net Charge (pH 7.4) 26.25

Charge Density (pH 7.0) 0.0565

GRAVY Index0.24

Hydrophobic Moment 0.81

Boman Index0.15

Instability Index38.60

Aliphatic Index 107.36

Aromaticity 0.0803

Extinction Coeff. Reduced 43890.00

Extinction Coeff. Oxidized 44015.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0076134 VERIFIED: NO

Provenance & Taxonomy

OrganismGadus morhua [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence