Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length467 amino acids

Chemical FormulaC2324H3718N588O652S13

DescriptionStandard

        CIIFISLHNYVLLCVGLSPKVKKKLLLAWWFTVLLKSRQIGIAALQEKFKTIKIPDLSGSESVSPIGKVSYSLTGIQILNLGLPESKLGLVPGTGVSLSIANAFINLHGNWRVKYLRIIKDSGSFDLAVSGLTISTTIAVKSDDTGRPAVSGVNCAATVGQARVKFHGGASWLYNLFSDYIDKALRSALQKQICPLVSDAINEMNPRLKTLNVLAQVDKYAEIEYSMVESPAVSNSSIDLSLKGEFYNIGQHKEPPFSPSPFSLPPQDSNMLYIGLSAFTPNSAGFVYNSAGALSLYITDDMIPPSSPIRLNTRTFGAFIPQIAKLYPGLMMKLLVKTAKEPTIIFKPNYVTLQVNSTVTAYAIQPNTTLSPLFILNVDASVSAKIYVTGIKVAGALTLNQIDMTLGTSYVGPFQVKSLDNIFLMVLKVAVIPKVNARLQQGYPLPAIGKMNLVNTQLQILKVQFNH
    

Molecular Weight50744.77 Da

Isoelectric Point (pI)9.51

Net Charge (pH 7.0)16.15

Net Charge (pH 7.4) 15.54

Charge Density (pH 7.0) 0.0346

GRAVY Index0.25

Hydrophobic Moment 0.76

Boman Index0.19

Instability Index32.63

Aliphatic Index 110.43

Aromaticity 0.0857

Extinction Coeff. Reduced 47330.00

Extinction Coeff. Oxidized 47580.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0168390 VERIFIED: NO

Provenance & Taxonomy

OrganismAstyanax mexicanus (Blind cave fish) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria