MYP_050815
Entianin
Antimicrobial
Antimicrobial
▸
Antibacterial
Antimicrobial
▸
Antibacterial
▸
Anti-Gram-positive
Standard
32 amino acids
C150H247N39O46S5
Standard
WKSESVCTPGCVTGLLQTCFLQTITCNCKISK
3493.12 Da
8.42
1.71
1.43
0.0534
0.29
0.38
0.13
41.07
79.06
0.0625
5500.00
5750.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
1378.89
-16.11
53.0
53.0
114.0
240.0
4.0
34.0
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0270347
VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis [Bacterium]
Bacteriocin
1423
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
named after the discover/author. Sequence analysis: Sequence similarity: This sequence differs from subtilin at three residues: L6V, A15L, L24I. Chemical modification: Linearization of entianin using Raney nickel catalyzed reductive cleavage enabled for the first time the use of tandem mass spectrometry for the fast and efficient determination of an entire lantibiotic primary structure, also including post-translational modifications. There are two di-dehydroalanines (Dha), S3, S31; one di-dehydrobutyrine (Dhb), T18; one lanthionine, S3-C7; and four methyllanthionines, T8-C11, T13-C19, T23-C26, and T25-C28
Bio-Activity Profile
Antimicrobial
Micrococcus luteus ATCC 9341
4-8 μg/mL
MIC
RECORD: Rec_0337460
VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 6.2%, T 34.4%, C 59.4% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial
Antimicrobial
RECORD: Rec_0363180
VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis subsp. spizizenii [Bacterium]
Bacteriocin
Structure & Mods
thioether-constrained cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Succinylation
None
There are two dehydroalanines (S5; S31),one dehydrobutyrine (T18),one lanthionine (S3-C7) and four β-methyllanthionines (T8-C11; T13-C19; T23-C26; T25-C28)
Bio-Activity Profile
Antimicrobial
Antibacterial
Staphylococcus aureus ATCC 29213
4-8 μg/mL
MIC
RECORD: Rec_0364948
VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis subsp. spizizenii [Bacterium]
Bacteriocin
Structure & Mods
thioether-constrained cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Succinylation
None
There are two dehydroalanines (S5; S31),one dehydrobutyrine (T18),one lanthionine (S3-C7) and four β-methyllanthionines (T8-C11; T13-C19; T23-C26; T25-C28)
Bio-Activity Profile
Antimicrobial
Antibacterial
RECORD: Rec_0384877
VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis subsp. spizizenii [Bacterium]
Bacteriocin
Structure & Mods
thioether-constrained cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Succinylation
None
There are two dehydroalanines (S5; S31),one dehydrobutyrine (T18),one lanthionine (S3-C7) and four β-methyllanthionines (T8-C11; T13-C19; T23-C26; T25-C28)
Bio-Activity Profile
Antimicrobial
Antibacterial
Enterococcus faecalis ATCC 29212
16 μg/mL
MIC
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