MYP_050815
Entianin
Antimicrobial
Antimicrobial
▸
Antibacterial
Antimicrobial
▸
Antibacterial
▸
Anti-Gram-positive
Standard
32 amino acids
C150H247N39O46S5
Standard
WKSESVCTPGCVTGLLQTCFLQTITCNCKISK
3493.12 Da
8.42
1.71
1.43
0.0534
0.29
0.38
0.13
41.07
79.06
0.0625
5500.00
5750.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
1378.89
-16.11
53.0
53.0
114.0
240.0
4.0
34.0
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0007458
VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
RECORD: Rec_0107438
VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis [Bacterium]
Bacteriocin
1423
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
named after the discover/author. Sequence analysis: Sequence similarity: This sequence differs from subtilin at three residues: L6V, A15L, L24I. Chemical modification: Linearization of entianin using Raney nickel catalyzed reductive cleavage enabled for the first time the use of tandem mass spectrometry for the fast and efficient determination of an entire lantibiotic primary structure, also including post-translational modifications. There are two di-dehydroalanines (Dha), S3, S31; one di-dehydrobutyrine (Dhb), T18; one lanthionine, S3-C7; and four methyllanthionines, T8-C11, T13-C19, T23-C26, and T25-C28
Bio-Activity Profile
Antimicrobial
Enterococcus faecalis ATCC 29212
16 μg/mL
MIC
RECORD: Rec_0129159
VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis DSM 15029T [Bacterium]
Bacteriocin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Antibacterial
Anti-Gram-positive
Staphylococcus aureus ATCC 29213
4-8 μg/mL
MIC
RECORD: Rec_0133938
VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis [Bacterium]
Bacteriocin
1423
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
named after the discover/author. Sequence analysis: Sequence similarity: This sequence differs from subtilin at three residues: L6V, A15L, L24I. Chemical modification: Linearization of entianin using Raney nickel catalyzed reductive cleavage enabled for the first time the use of tandem mass spectrometry for the fast and efficient determination of an entire lantibiotic primary structure, also including post-translational modifications. There are two di-dehydroalanines (Dha), S3, S31; one di-dehydrobutyrine (Dhb), T18; one lanthionine, S3-C7; and four methyllanthionines, T8-C11, T13-C19, T23-C26, and T25-C28
Bio-Activity Profile
Antimicrobial
several Gram-positive pathogens, such as Staphylococcus aureus ATCC 29213
4-8 μg/mL
MIC
RECORD: Rec_0143209
VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis DSM 15029T [Bacterium]
Bacteriocin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Antibacterial
Anti-Gram-positive
Micrococcus luteus ATCC 9341
4-8 μg/mL
MIC
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