Peptide Database

Peptide NameSLAY-screened peptide P2986

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC89H143N25O25S

DescriptionStandard

        VRTPLCTPSAAHGGLPVFTA
    

Molecular Weight1995.31 Da

Isoelectric Point (pI)8.23

Net Charge (pH 7.0)0.81

Net Charge (pH 7.4) 0.54

Charge Density (pH 7.0) 0.0406

GRAVY Index0.53

Hydrophobic Moment 0.28

Boman Index0.28

Instability Index51.43

Aliphatic Index 83.00

Aromaticity 0.0500

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 761.35

LogP -8.61

H-bond Donors 27.0

H-bond Acceptors 28.0

Rotatable Bonds 55.0

Heavy Atoms 140.0

Ring Count 5.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0138232 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/