Peptide Database

Peptide NameLantibiotic

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length66 amino acids

Chemical FormulaC337H543N87O98S5

DescriptionStandard

        MEEKMCLGALNALQEFQIEELDNLLGGGGMVSIQFQLNVVGIVYRQFLLVVNMFRSKEYESKRTVI
    

Molecular Weight7541.76 Da

Isoelectric Point (pI)4.90

Net Charge (pH 7.0)-2.49

Net Charge (pH 7.4) -2.74

Charge Density (pH 7.0) -0.0378

GRAVY Index0.21

Hydrophobic Moment 0.55

Boman Index0.13

Instability Index52.87

Aliphatic Index 110.61

Aromaticity 0.0909

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3026.17

LogP -23.37

H-bond Donors 103.0

H-bond Acceptors 101.0

Rotatable Bonds 263.0

Heavy Atoms 527.0

Ring Count 6.0

Amide Bonds 74.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0376636 VERIFIED: NO

Provenance & Taxonomy

OrganismStreptococcus pyogenes [Bacterium]

FamilyLantibiotic

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Bacteriocin Lantibiotic Anti-Gram-positive Non-hemolytic Non-ribosomal

TargetGram-positive bacteria

MethodQualitative functional evidence