Peptide Database

Peptide NameHill-Def 5

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Standard StatusStandard

Sequence Length40 amino acids

Chemical FormulaC174H291N59O52S9

DescriptionStandard

        AMCDLLSGLNMGRSVCAMRCILKGHRGGWCDDQGVCNCRV
    

Molecular Weight4330.12 Da

Isoelectric Point (pI)8.36

Net Charge (pH 7.0)1.83

Net Charge (pH 7.4) 1.50

Charge Density (pH 7.0) 0.0457

GRAVY Index0.14

Hydrophobic Moment 0.70

Boman Index-0.00

Instability Index32.38

Aliphatic Index 75.50

Aromaticity 0.0250

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5875.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1797.94

LogP -21.53

H-bond Donors 70.0

H-bond Acceptors 64.0

Rotatable Bonds 146.0

Heavy Atoms 294.0

Ring Count 3.0

Amide Bonds 42.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0417523 VERIFIED: YES

Provenance & Taxonomy

OrganismHermetia illucens [Animal]

FamilyDefensin

Tax ID343691

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetMRC-5 SV2

Activity32 μM

MethodIC50

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