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MYP_050715
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Basic Information
Unnamed
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Standard
3 amino acids
C13H25N3O4
Standard
Sequence
AVV
Physicochemical Analysis
287.36 Da
5.57
-0.20
-0.39
-0.0680
3.40
0.30
0.93
6.67
226.67
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
121.52
-0.30
4.0
4.0
7.0
20.0
0.0
2.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0016620 VERIFIED: YES
Provenance & Taxonomy
Sepia officinalis [Animal]
ACE-inhibitory peptide
6610
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
ACE
66.6 μM
IC50
PaperAnalysis of novel angiotensin I-converting enzyme inhibitory peptides from enzymatic hydrolysates of cuttlefish (Sepia officinalis) muscle proteins PMID20180574 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20180574/
RECORD: Rec_0085364 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
Angiotensin-converting enzyme (ACE)
66.6
IC50
PaperBalti R., Nedjar-Arroume N., Adje E. Y., Guillochon D., Nasri M.. Analysis of novel angiotensin I-converting enzyme inhibitory peptides from enzymatic hydrolysates of cuttlefish (Sepia officinalis) muscle proteins. J. Agric. Food Chem., 58, 5763-5769, 2010.
RECORD: Rec_0107169 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Source entry describes small-molecule/peptide conjugation at one terminus; exact terminus not explicitly assigned in source metadata
Conjugate type: amide; Conjugated small molecule: Phorphirine derivative
Bio-Activity Profile
-
PaperTurn and helical peptide spacers: combined distance and angular dependencies in the exciton-coupled circular dichroism of intramolecularly interacting bis-porphyrins Evidence URLhttps://doi.org/10.1002/bip.20500
RECORD: Rec_0181527 VERIFIED: YES
Provenance & Taxonomy
Sepia officinalis [Animal]
Angiotensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Enzyme inhibitory Neuropeptide ACE inhibitory
Angiotensin-converting enzyme
66.6 μM
IC50
RECORD: Rec_0246660 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 0.0%, C 100.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antihypertensive
PaperAHTPDB: a comprehensive platform for analysis and presentation of antihypertensive peptides PMID25392419 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25392419/
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