Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length494 amino acids

Chemical FormulaC2461H3891N635O712S14

DescriptionStandard

        MKLWLPFILLVCGTIKCEEPGIKGRLTLKGLHYGWQVMLKELQRRLSSLPIPDVSGSVSVPVLGRIYYSVSSLQIQELDLSHSDASFSTDTGLQVSVSDGRTRVTGYIEIRTVLFGASASLEVSVNGLYLSAVLGLTRDDLGHGAIWNAGCSSSAGQVDLHFHGGSGWIFNMFKGSILGPIHDAFSQQLCPQFDKTVMQMEKLLSSLPVTQPVDSVAALEVALVSPPLITEQNVDLLVKGQFVGLSQHWDIPYSPVEIDLPDADSAVVFAVSQFSANSAAYVHYKSGLLRANITDNMIPKESPFRLNTKSFAAFAPELPNRFPDSPPLLLQVSAQSPPEVTCQADLLTLSVSLDLQVSALYPQRPLVPVFELQADFETQINILLSEETMGAQLALRNFSLALLHSDAGPVKVEQLQRMMSFALKGIIFPLLNKKLQNIFLIPTPLVRLQNPTVRVFQGYLVVVSDLEIDIWTQPQKILDVAWEIPKRHQSSTSL
    

Molecular Weight54214.96 Da

Isoelectric Point (pI)5.50

Net Charge (pH 7.0)-9.62

Net Charge (pH 7.4) -10.51

Charge Density (pH 7.0) -0.0195

GRAVY Index0.17

Hydrophobic Moment 0.67

Boman Index0.16

Instability Index46.42

Aliphatic Index 108.68

Aromaticity 0.0789

Extinction Coeff. Reduced 53400.00

Extinction Coeff. Oxidized 53650.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0010880 VERIFIED: NO

Provenance & Taxonomy

OrganismXenopus laevis [Animal]

FamilyBPI/LBP

Tax ID8355

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence