Peptide Database

Peptide NameUroguanylin

Function Ontology

Cardiovascular

Metabolic ▸ Appetite and feeding regulation ▸ Feeding regulator

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC60H100N16O25S4

DescriptionStandard

        TDECELCINVACTGC
    

Molecular Weight1573.79 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-3.63

Net Charge (pH 7.4) -3.89

Charge Density (pH 7.0) -0.2423

GRAVY Index0.57

Hydrophobic Moment 0.26

Boman Index0.17

Instability Index83.99

Aliphatic Index 78.00

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 250.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 666.17

LogP -8.85

H-bond Donors 26.0

H-bond Acceptors 26.0

Rotatable Bonds 50.0

Heavy Atoms 105.0

Ring Count 0.0

Amide Bonds 15.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0016032 VERIFIED: NO

Provenance & Taxonomy

OrganismNotomys alexis [Animal]

FamilyUroguanylin

Tax ID184396

Structure & Mods

Configlinear peptide with reported disulfide constraint [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide4-12; 7-15

Bio-Activity Profile

Function

Receptor modulation

Half-LifeMammalian: 7.2 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0059145 VERIFIED: YES

Provenance & Taxonomy

OrganismMus musculus [Animal]

FamilyUroguanylin

Tax ID10090

Structure & Mods

Configlinear peptide with reported disulfide constraint [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide4-12; 7-15

Bio-Activity Profile

Function

Cardiovascular Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation Feeding regulator

Half-LifeMammalian: 7.2 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0160845 VERIFIED: NO

Provenance & Taxonomy

OrganismMus musculus [Animal]; Rattus norvegicus [Animal]

Tax ID10090, 10116

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide4-12; 7-15

Bio-Activity Profile

Function

cGMP Activator

RECORD: Rec_0225762 VERIFIED: YES

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyUroguanylin

Tax ID10116

Structure & Mods

Configlinear peptide with reported disulfide constraint [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide4-12; 7-15

Bio-Activity Profile

Function

Cardiovascular Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation Feeding regulator

Half-LifeMammalian: 7.2 hour; Yeast: >20 hour; E. coli: >10 hour