Peptide Database

Peptide NameBeta-mammal toxin Cn2

Function Ontology

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity

Membrane / Ion-channel modulation ▸ Ion channel inhibition

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor

Venom / Toxin ▸ General toxin ▸ Toxin

Venom / Toxin ▸ Toxin

Standard StatusStandard

Sequence Length66 amino acids

Chemical FormulaC336H503N89O97S8

DescriptionStandard

        KEGYLVDKNTGCKYECLKLGDNDYCLRECKQQYGKGAGGYCYAFACWCTHLYEQAIVWPLPNKRCS
    

Molecular Weight7597.65 Da

Isoelectric Point (pI)8.15

Net Charge (pH 7.0)1.77

Net Charge (pH 7.4) 1.37

Charge Density (pH 7.0) 0.0268

GRAVY Index-0.58

Hydrophobic Moment 0.49

Boman Index-0.06

Instability Index52.28

Aliphatic Index 56.21

Aromaticity 0.1515

Extinction Coeff. Reduced 21430.00

Extinction Coeff. Oxidized 21930.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3025.38

LogP -26.72

H-bond Donors 112.0

H-bond Acceptors 108.0

Rotatable Bonds 247.0

Heavy Atoms 530.0

Ring Count 15.0

Amide Bonds 71.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0225702 VERIFIED: YES

Provenance & Taxonomy

OrganismCentruroides noxius [Animal]

FamilySodium channel inhibitor family

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Disulfide12-65; 16-41; 25-46; 29-48

Bio-Activity Profile

Function

Toxin Venom Sodium channel inhibitor family Ion channel inhibitor Host defense