Peptide Database

Peptide Name[Ac-D-2Nal1,D4CPA2,D-3Pal3,6,Leu8, D-Ala10]GnRH-II

Function Ontology

Neurological / Signaling ▸ Receptor modulation ▸ Agonist

Neurological / Signaling ▸ Receptor modulation ▸ Antagonist

Neurological / Signaling ▸ Signaling peptide

Standard StatusStandard

Sequence Length10 amino acids

Chemical FormulaC52H71N13O12

DescriptionStandard

        AFASHAWLPA
    

Molecular Weight1070.20 Da

Isoelectric Point (pI)6.79

Net Charge (pH 7.0)-0.12

Net Charge (pH 7.4) -0.36

Charge Density (pH 7.0) -0.0117

GRAVY Index0.73

Hydrophobic Moment 0.11

Boman Index0.51

Instability Index59.86

Aliphatic Index 79.00

Aromaticity 0.2000

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 381.13

LogP -1.68

H-bond Donors 13.0

H-bond Acceptors 13.0

Rotatable Bonds 27.0

Heavy Atoms 77.0

Ring Count 5.0

Amide Bonds 9.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0274664 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

FamilyGtoPdb peptide ligand

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

Bio-Activity Profile

Function

Receptor antagonist Signaling peptide

TargetGnRH1 receptor (Human)

Activity0.66 nM

MethodIC50