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MYP_050288
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Basic Information
WRL3
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
18 amino acids
C105H183N43O19
Standard
Sequence
WLRAFRRLVRRLARGLRR
Physicochemical Analysis
2351.85 Da
12.00
7.76
7.56
0.4311
-0.64
1.18
-0.62
128.45
113.89
0.1111
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1069.01
-7.78
44.0
27.0
80.0
167.0
3.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0294381 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic
human red blood cells
PaperInsights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles. J Med Chem. 2016 Dec 22;59(24):10946-10962. doi: 10.1021/acs.jmedchem.6b00922. PMID: 28002968. PMID28002968 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28002968/
RECORD: Rec_0322650 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Salmonella paratyphi paratyphi-B 21495
0.85 μM
MIC
PaperInsights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles. J Med Chem. 2016 Dec 22;59(24):10946-10962. doi: 10.1021/acs.jmedchem.6b00922. PMID: 28002968. PMID28002968 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28002968/
RECORD: Rec_0325785 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Micrococcus luteus 28001
0.43 μM
MIC
PaperInsights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles. J Med Chem. 2016 Dec 22;59(24):10946-10962. doi: 10.1021/acs.jmedchem.6b00922. PMID: 28002968. PMID28002968 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28002968/
RECORD: Rec_0328668 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Pseudomonas fluorescens 21620
0.43 μM
MIC
PaperInsights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles. J Med Chem. 2016 Dec 22;59(24):10946-10962. doi: 10.1021/acs.jmedchem.6b00922. PMID: 28002968. PMID28002968 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28002968/
RECORD: Rec_0336386 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Salmonella typhimurium 51005
6.81 μM
MIC
PaperInsights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles. J Med Chem. 2016 Dec 22;59(24):10946-10962. doi: 10.1021/acs.jmedchem.6b00922. PMID: 28002968. PMID28002968 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28002968/
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