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MYP_050274
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Basic Information
BLfcinB 17-42
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Antiviral ▸ Anti-HPV
Antiviral ▸ Antiviral mechanism ▸ Pseudovirus inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Standard
26 amino acids
C144H231N47O30S3
Standard
Sequence
FKCRRWQWRMKKLGAPSITCVRRAFA
Physicochemical Analysis
3196.87 Da
11.84
7.74
7.50
0.2976
-0.48
0.57
-0.27
75.31
52.69
0.1538
11000.00
11125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1284.72
-9.65
51.0
41.0
105.0
224.0
7.0
26.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0007414 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-20
Disulfide bonds between Cys3 and Cys20.
Bio-Activity Profile
Antiviral Anti-HPV Pseudovirus inhibition
Human papillomavirus(HPV) | C33A cells
0.25±0.24 μM
IC50
Mammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min
PaperThe anti-papillomavirus activity of human and bovine lactoferricin. | Mistry N, Drobni P, Näslund J, Sunkari VG, Jenssen H, Evander M. | Antiviral Res. 2007 Sep;75(3):258-65. | DOI:10.1016/j.antiviral.2007.03.012 | PMID:17481742 PMID17481742 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17481742/
RECORD: Rec_0024788 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Lactoferricin
9913
Structure & Mods
linear peptide with reported disulfide constraint [Linear]
canonical L-amino-acid peptide [L]
3-20
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli; Staphylococcus aureus; Bacillus cereus; Listeria monocytogenes; Pseudomonas fluorescens
MIC
PaperAntibacterial activity in bovine lactoferrin-derived peptides | Hoek, KS. et al. | DOI: 10.1128/aac.41.1.54 Evidence URLhttps://www.uniprot.org/uniprotkb/P24627/entry
RECORD: Rec_0097589 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-20
Bio-Activity Profile
Antimicrobial Antiviral
human papillomavirus(HPV):inhibition of pseudovirus infection in C33A cells
0.25±0.24 μM
IC50
PaperPubMed PMID: 17481742 PMID17481742 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17481742/
RECORD: Rec_0112163 VERIFIED: NO
Provenance & Taxonomy
Bos taurus [Animal]
Lactoferricin
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0125901 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Lactoferrin-derived
9913;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
Human papillomavirus (Virus entry); HaCaT
9.7 μM
Western blotting
PaperThe anti-papillomavirus activity of human and bovine lactoferricin. | Mistry N, Drobni P, Naslund J, Sunkari VG, Jenssen H, Evander M. | Antiviral Res. 2007 | PMID:17481742 PMID17481742 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17481742/
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