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MYP_050224
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Basic Information
Lactoglobulin beta [146-149]
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Metabolic ▸ Lipid metabolism ▸ Cholesterol-lowering
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Standard
4 amino acids
C24H43N9O5
Standard
Sequence
HIRL
Physicochemical Analysis
537.66 Da
9.76
0.85
0.59
0.2118
0.15
0.65
-0.12
117.35
195.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
241.20
-0.83
9.0
7.0
17.0
38.0
1.0
3.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0039022 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide Enzyme inhibitory ACE inhibitory
Angiotensin-converting enzyme
1153 μM
IC50
RECORD: Rec_0051916 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Neurotensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hypocholesterolemic
PaperYamauchi R., Ohinata K., Yoshikawa M.. Beta-lactotensin and neurotensin rapidly reduce serum cholesterol via the NT2 receptor. Peptides, 24, 1955-1961, 2003.
RECORD: Rec_0166348 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
ACE-inhibitory peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
ACE
2.94 pIC50
pIC50
PaperWhat are the ideal properties for functional food peptides with antihypertensive effect? A computational peptidology approach. PMID23871047 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23871047/
RECORD: Rec_0173265 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
Angiotensin-converting enzyme (ACE)
1153.0
IC50
PaperMullally M. M., Meisel H., FitzGerald R. J.. Synthetic peptides corresponding to alpha-lactalbumin and beta-lactoglobulin sequences with angiotensin-I-converting enzyme inhibitory activity. Biol. Chem. Hoppe-Seyler, 377, 259-261, 1996.
RECORD: Rec_0175300 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Lactotensin
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anxiolytic
Mice
PaperEffect of β-lactotensin on acute stress and fear memory | Yamauchi, R. et al. | DOI: 10.1016/j.peptides.2006.08.009 Evidence URLhttps://www.uniprot.org/uniprotkb/P02754/entry
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