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MYP_050186
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Basic Information
Brevinin-2LF2
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
33 amino acids
C148H258N40O43S3
Standard
Sequence
SIMSTLKQFGISAIKGAAQNVLGVLSCKIAKTC
Physicochemical Analysis
3382.07 Da
9.70
3.44
3.19
0.1041
0.69
0.46
0.24
22.33
112.42
0.0303
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1349.25
-14.97
49.0
50.0
118.0
234.0
1.0
35.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0072093 VERIFIED: YES
Provenance & Taxonomy
Hylarana taipehensis [Animal]
Brevinin
110118
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
27-33
Bio-Activity Profile
Antimicrobial Antioxidant
E. cloacae CGMCC 1.57
100 μM
MIC
PaperIdentification of multiple peptides with antioxidant and antimicrobial activities from skin and its secretions of Hylarana taipehensis, Amolops lifanensis, and Amolops granulosus PMID25066917 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25066917/
RECORD: Rec_0079563 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 66.7%, E 0.0%, T 9.1%, C 24.2% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial Anti-Gram-positive Anti-Gram-negative
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0081045 VERIFIED: YES
Provenance & Taxonomy
Amolops lifanensis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
25 μM
MIC
RECORD: Rec_0083181 VERIFIED: YES
Provenance & Taxonomy
Amolops lifanensis [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
27-33
Bio-Activity Profile
Antimicrobial Antibacterial
PaperJ.M. Conlon et al. / Peptides 28 (2007) 1268-1274. Peptide defenses of the Cascades frog Rana cascadae: implications for the evolutionary history of frogs of the Amerana species group PMID17451843 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17451843/
RECORD: Rec_0084158 VERIFIED: YES
Provenance & Taxonomy
Hylarana taipehensis [Animal]
Brevinin
110118
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
27-33
Bio-Activity Profile
Antimicrobial Antioxidant
P. faecalis X29
6.3 μM
MIC
PaperIdentification of multiple peptides with antioxidant and antimicrobial activities from skin and its secretions of Hylarana taipehensis, Amolops lifanensis, and Amolops granulosus PMID25066917 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25066917/
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