‹ ›
MYP_050156
← PREVIOUS NEXT → BACK
Basic Information
A12L/A20L
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
26 amino acids
C145H242N36O34
Standard
Sequence
KWKSFLKTFKSLKKTVLHTLLKAISS
Physicochemical Analysis
3033.69 Da
10.78
6.84
6.58
0.2631
-0.06
0.69
-0.01
3.29
105.00
0.1154
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1159.04
-7.34
43.0
42.0
107.0
215.0
5.0
25.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0136271 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Acetylation
Amidation
Bio-Activity Profile
Anticancer
Human erythrocytes
81.31±0.17 μM
MHC
Paperhttps://pubmed.ncbi.nlm.nih.gov/22837667/ PMID22837667 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22837667/
RECORD: Rec_0138039 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
noncanonical stereochemical modification [Modified]
Bio-Activity Profile
Anticancer
Cancer cell: HeLa cell
1.52±0.05 μM
IC50
PaperRole of helicity on the anticancer mechanism of action of cationic-helical peptides. Int J Mol Sci. 2012 Jun;13(6):6849-6862. doi: 10.3390/ijms13066849. PMID: 22837667. PMID22837667 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22837667/
RECORD: Rec_0142069 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperPatent US 2009/0005300 A1 Evidence URLhttps://patents.google.com/patent/US20090005300A1/en PatentUS 2009/0005300 A1
RECORD: Rec_0146052 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
noncanonical stereochemical modification [Modified]
Bio-Activity Profile
Anticancer
Cancer cell: HeLa cell
3.14±0.06 μM
IC50
PaperRole of helicity on the anticancer mechanism of action of cationic-helical peptides. Int J Mol Sci. 2012 Jun;13(6):6849-6862. doi: 10.3390/ijms13066849. PMID: 22837667. PMID22837667 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22837667/
RECORD: Rec_0147332 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Acetylation
Amidation
Bio-Activity Profile
Anticancer
Human erythrocytes
20.81±0.1 μM
MHC
Paperhttps://pubmed.ncbi.nlm.nih.gov/22837667/ PMID22837667 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22837667/
FIRST PREV 1 ... 5 6 7 8 9 ... 19 NEXT LAST
Showing 5 records on this page · Page 7 of 19