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MYP_050156
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Basic Information
A12L/A20L
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
26 amino acids
C145H242N36O34
Standard
Sequence
KWKSFLKTFKSLKKTVLHTLLKAISS
Physicochemical Analysis
3033.69 Da
10.78
6.84
6.58
0.2631
-0.06
0.69
-0.01
3.29
105.00
0.1154
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1159.04
-7.34
43.0
42.0
107.0
215.0
5.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0275789 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
A12L/A20L
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Acetylation
Amidation
Bio-Activity Profile
Anticancer Cytotoxic
HeLa
2.23±0.10 μM
IC50
PMID22837667 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22837667/
RECORD: Rec_0277726 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
noncanonical stereochemical modification [Modified]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Pseudomonas aeruginosa PAO1
62.5 μg/mL
MIC
PaperPubMed PMID: 17158938 | Role of helicity on the anticancer mechanism of action of cationic-helical peptides. Int J Mol Sci. 2012 Jun;13(6):6849-6862. doi: 10.3390/ijms13066849. PMID: 22837667. PMID17158938;22837667 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17158938/
RECORD: Rec_0278459 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
noncanonical stereochemical modification [Modified]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative Antiplasmodial
PaperRole of helicity on the anticancer mechanism of action of cationic-helical peptides. Int J Mol Sci. 2012 Jun;13(6):6849-6862. doi: 10.3390/ijms13066849. PMID: 22837667. PMID22837667 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22837667/
RECORD: Rec_0283199 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
noncanonical stereochemical modification [Modified]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Pseudomonas aeruginosa M2
62.5 μg/mL
MIC
PaperPubMed PMID: 17158938 | Role of helicity on the anticancer mechanism of action of cationic-helical peptides. Int J Mol Sci. 2012 Jun;13(6):6849-6862. doi: 10.3390/ijms13066849. PMID: 22837667. PMID17158938;22837667 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17158938/
RECORD: Rec_0288158 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
A12L/A20L
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Acetylation
Amidation
Bio-Activity Profile
Anticancer Cytotoxic
HeLa
20.41±0.64 μM
IC50
PMID22837667 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22837667/
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