Peptide Database

Peptide NameSLAY-screened peptide P2753

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC75H112N22O24S2

DescriptionStandard

        AVSRMFNNDTLDCHF
    

Molecular Weight1769.95 Da

Isoelectric Point (pI)5.21

Net Charge (pH 7.0)-1.12

Net Charge (pH 7.4) -1.38

Charge Density (pH 7.0) -0.0750

GRAVY Index-0.23

Hydrophobic Moment 0.39

Boman Index-0.03

Instability Index26.97

Aliphatic Index 52.00

Aromaticity 0.1333

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 762.54

LogP -8.62

H-bond Donors 27.0

H-bond Acceptors 26.0

Rotatable Bonds 56.0

Heavy Atoms 123.0

Ring Count 3.0

Amide Bonds 16.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0074291 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/