Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length126 amino acids

Chemical FormulaC635H987N159O177S5

DescriptionStandard

        MLPSVMVVFAILSCTRGKNPAVQVTLTDKWLQYVKHVGAGWIQDKLEHITFPDISGDVDILIGHVYYTLSGIRITKCDLPEPVLEFFQSTGLKTSIVGLNAALVGNWRTSFGIIHDGGSFDMAIFS
    

Molecular Weight13840.91 Da

Isoelectric Point (pI)6.01

Net Charge (pH 7.0)-2.16

Net Charge (pH 7.4) -2.63

Charge Density (pH 7.0) -0.0172

GRAVY Index0.36

Hydrophobic Moment 0.58

Boman Index0.25

Instability Index33.77

Aliphatic Index 106.67

Aromaticity 0.1032

Extinction Coeff. Reduced 20970.00

Extinction Coeff. Oxidized 21095.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 5297.54

LogP -42.10

H-bond Donors 185.0

H-bond Acceptors 184.0

Rotatable Bonds 448.0

Heavy Atoms 976.0

Ring Count 25.0

Amide Bonds 132.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0157361 VERIFIED: NO

Provenance & Taxonomy

OrganismNothobranchius pienaari [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria