Peptide Database

Peptide NameThyroliberin

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Metabolic ▸ Appetite and feeding regulation ▸ Feeding regulator

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological regulation

Regulatory peptide ▸ Cell-cell communication

Standard StatusStandard

Sequence Length3 amino acids

Chemical FormulaC16H24N6O5

DescriptionStandard

QHP

Molecular Weight380.40 Da

Isoelectric Point (pI)6.74

Net Charge (pH 7.0)-0.15

Net Charge (pH 7.4) -0.41

Charge Density (pH 7.0) -0.0509

GRAVY Index-2.77

Hydrophobic Moment 0.33

Boman Index-0.38

Instability Index-2.93

Aliphatic Index 0.00

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 184.50

LogP -1.89

H-bond Donors 5.0

H-bond Acceptors 6.0

Rotatable Bonds 9.0

Heavy Atoms 27.0

Ring Count 2.0

Amide Bonds 3.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0427355 VERIFIED: YES

Provenance & Taxonomy

OrganismDanio rerio [Animal]

FamilyThyroliberin

Tax ID7955

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermPyroglutamate

C-TermAmidation

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator

Targetthe anterior pituitary gland

Half-LifeExperimental: ~20 minutes; /1200 seconds; Mammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour

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