Peptide Database

Peptide NameDermaseptin-H3 (DRS-H3) (DShypo 01) (Dermaseptin DPh-1)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Antiparasitic ▸ Antiprotozoal

Antiparasitic ▸ General antiparasitic ▸ Antiparasitic

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length70 amino acids

Chemical FormulaC341H556N88O109S4

DescriptionStandard

        MAFLKKSLFLVLFLGMVSLSICEEEKRENEDEELQEDDEQSEMKRGLWSTIKNVGKEAAIAAGKAALGAL
    

Molecular Weight7760.85 Da

Isoelectric Point (pI)4.64

Net Charge (pH 7.0)-5.48

Net Charge (pH 7.4) -5.74

Charge Density (pH 7.0) -0.0783

GRAVY Index-0.17

Hydrophobic Moment 0.64

Boman Index0.02

Instability Index54.49

Aliphatic Index 96.29

Aromaticity 0.0571

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3208.89

LogP -27.64

H-bond Donors 110.0

H-bond Acceptors 108.0

Rotatable Bonds 277.0

Heavy Atoms 542.0

Ring Count 5.0

Amide Bonds 73.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0002001 VERIFIED: YES

Provenance & Taxonomy

OrganismPithecopus hypochondrialis [Animal]

FamilyDermaseptin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antiparasitic Antiprotozoal Anti-Gram-negative Anti-Gram-positive Hemolytic

TargetPseudomonas aeruginosa (Gram-negative)

RECORD: Rec_0122356 VERIFIED: YES

Provenance & Taxonomy

OrganismPithecopus hypochondrialis [Animal]

FamilyDermaseptin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antiparasitic Antiprotozoal Anti-Gram-negative Anti-Gram-positive Hemolytic

TargetStaphylococcus aureus (Gram-positive)

RECORD: Rec_0136087 VERIFIED: YES

Provenance & Taxonomy

OrganismPithecopus hypochondrialis [Animal]

FamilyDermaseptin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antiparasitic Antiprotozoal Anti-Gram-negative Anti-Gram-positive Hemolytic

TargetEscherichia coli (Gram-negative)