MYP_049863
Turgencin B
Anticancer
Anticancer
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Cytotoxic anticancer activity
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Cytotoxic
Antimicrobial
Antimicrobial
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Antibacterial
Antimicrobial
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Antibacterial
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Anti-Gram-negative
Antimicrobial
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Antibacterial
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Anti-Gram-positive
Toxicity / Safety
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Cytotoxicity
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Cytotoxic
Toxicity / Safety
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Negative safety assay result
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Non-hemolytic
Venom / Toxin
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General toxin
▸
Cytotoxic
Standard
35 amino acids
C143H248N42O46S8
Standard
GIKEMLCNMACAQTVCKKSGGPLCDTCQAACKALG
3548.27 Da
8.33
1.70
1.40
0.0486
0.27
0.43
0.10
36.08
67.14
0.0000
0.00
375.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
1412.57
-18.05
53.0
56.0
121.0
239.0
1.0
37.0
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0235802
VERIFIED: YES
Provenance & Taxonomy
Synoicum turgens [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
APD analysis reveals that this sequence is most similar (43.6%) to Turgencin A. Chemical modification: Six cysteines has an unusual disulfide connectivity of Cys1-Cys6, Cys2-Cys5, and Cys3-Cys4 and an amidated C-terminus. Variation in peptide oxidation (M) has been observed. 67% Mox0, 29% Mox1, 4% Mox2. The first methionine is preferentially oxidized. Structure: NMR analysis reveals a possible C1-C6/C2-C5/C3-C4 disulfide pattern. It is likely that the peptide has some helical feture because both sample heterogeneity and peptide conformational dynamics caused a problem
Bio-Activity Profile
Antimicrobial
Anticancer
Pseudomonas aeruginosa, A2058
25 μM
MIC
RECORD: Rec_0246366
VERIFIED: YES
Provenance & Taxonomy
Synoicum turgens [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
APD analysis reveals that this sequence is most similar (43.6%) to Turgencin A. Chemical modification: Six cysteines has an unusual disulfide connectivity of Cys1-Cys6, Cys2-Cys5, and Cys3-Cys4 and an amidated C-terminus. Variation in peptide oxidation (M) has been observed. 67% Mox0, 29% Mox1, 4% Mox2. The first methionine is preferentially oxidized. Structure: NMR analysis reveals a possible C1-C6/C2-C5/C3-C4 disulfide pattern. It is likely that the peptide has some helical feture because both sample heterogeneity and peptide conformational dynamics caused a problem
Bio-Activity Profile
Antimicrobial
Anticancer
Corynebacterium glutamicum
1.6 μM
MIC
RECORD: Rec_0259571
VERIFIED: YES
Provenance & Taxonomy
Synoicum turgens [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Antibacterial
Staphylococcus aureus ATCC 9144
100 μM
MIC
RECORD: Rec_0266786
VERIFIED: YES
Provenance & Taxonomy
Synoicum turgens [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Anti-Gram-negative
Anti-Gram-positive
Non-hemolytic
Bacillus subtilis (Gram-positive)
RECORD: Rec_0272493
VERIFIED: YES
Provenance & Taxonomy
Synoicum turgens [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
APD analysis reveals that this sequence is most similar (43.6%) to Turgencin A. Chemical modification: Six cysteines has an unusual disulfide connectivity of Cys1-Cys6, Cys2-Cys5, and Cys3-Cys4 and an amidated C-terminus. Variation in peptide oxidation (M) has been observed. 67% Mox0, 29% Mox1, 4% Mox2. The first methionine is preferentially oxidized. Structure: NMR analysis reveals a possible C1-C6/C2-C5/C3-C4 disulfide pattern. It is likely that the peptide has some helical feture because both sample heterogeneity and peptide conformational dynamics caused a problem
Bio-Activity Profile
Antimicrobial
Anticancer
the human melanoma cancer cell line A2058
4.1 μM
IC50
Showing 5 records on this page · Page 4 of 6