MYP_049863
Turgencin B
Anticancer
Anticancer
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Cytotoxic anticancer activity
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Cytotoxic
Antimicrobial
Antimicrobial
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Antibacterial
Antimicrobial
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Antibacterial
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Anti-Gram-negative
Antimicrobial
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Antibacterial
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Anti-Gram-positive
Toxicity / Safety
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Cytotoxicity
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Cytotoxic
Toxicity / Safety
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Negative safety assay result
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Non-hemolytic
Venom / Toxin
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General toxin
▸
Cytotoxic
Standard
35 amino acids
C143H248N42O46S8
Standard
GIKEMLCNMACAQTVCKKSGGPLCDTCQAACKALG
3548.27 Da
8.33
1.70
1.40
0.0486
0.27
0.43
0.10
36.08
67.14
0.0000
0.00
375.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
1412.57
-18.05
53.0
56.0
121.0
239.0
1.0
37.0
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0081818
VERIFIED: YES
Provenance & Taxonomy
Synoicum turgens [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
APD analysis reveals that this sequence is most similar (43.6%) to Turgencin A. Chemical modification: Six cysteines has an unusual disulfide connectivity of Cys1-Cys6, Cys2-Cys5, and Cys3-Cys4 and an amidated C-terminus. Variation in peptide oxidation (M) has been observed. 67% Mox0, 29% Mox1, 4% Mox2. The first methionine is preferentially oxidized. Structure: NMR analysis reveals a possible C1-C6/C2-C5/C3-C4 disulfide pattern. It is likely that the peptide has some helical feture because both sample heterogeneity and peptide conformational dynamics caused a problem
Bio-Activity Profile
Antimicrobial
Anticancer
non-malignant human fibroblast cell line MRC-5
7.5 μM
IC50
RECORD: Rec_0081945
VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Anticancer
RECORD: Rec_0086925
VERIFIED: YES
Provenance & Taxonomy
Synoicum turgens [Animal]
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
7-31, 11-27, 16-24
Bio-Activity Profile
Antimicrobial
Antibacterial
Anti-Gram-positive
Anti-Gram-negative
Anticancer
Cytotoxic
Cytotoxicity:Human fibroblasts MRC-5
7.5 μM
IC50
RECORD: Rec_0140904
VERIFIED: YES
Provenance & Taxonomy
Synoicum turgens [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
APD analysis reveals that this sequence is most similar (43.6%) to Turgencin A. Chemical modification: Six cysteines has an unusual disulfide connectivity of Cys1-Cys6, Cys2-Cys5, and Cys3-Cys4 and an amidated C-terminus. Variation in peptide oxidation (M) has been observed. 67% Mox0, 29% Mox1, 4% Mox2. The first methionine is preferentially oxidized. Structure: NMR analysis reveals a possible C1-C6/C2-C5/C3-C4 disulfide pattern. It is likely that the peptide has some helical feture because both sample heterogeneity and peptide conformational dynamics caused a problem
Bio-Activity Profile
Antimicrobial
Anticancer
Bacillus subtilis
1.6 μM
MIC
RECORD: Rec_0143256
VERIFIED: YES
Provenance & Taxonomy
Synoicum turgens [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Anti-Gram-negative
Anti-Gram-positive
Non-hemolytic
Pseudomonas aeruginosa (Gram-negative)
Showing 5 records on this page · Page 2 of 6