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MYP_049863
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Basic Information
Turgencin B
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
35 amino acids
C143H248N42O46S8
Standard
Sequence
GIKEMLCNMACAQTVCKKSGGPLCDTCQAACKALG
Physicochemical Analysis
3548.27 Da
8.33
1.70
1.40
0.0486
0.27
0.43
0.10
36.08
67.14
0.0000
0.00
375.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1412.57
-18.05
53.0
56.0
121.0
239.0
1.0
37.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0001190 VERIFIED: YES
Provenance & Taxonomy
Synoicum turgens [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Cytotoxic
Human fibroblasts MRC-5
7.5 μM
IC50
PMID31940927 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31940927/
RECORD: Rec_0028798 VERIFIED: YES
Provenance & Taxonomy
Synoicum turgens [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
APD analysis reveals that this sequence is most similar (43.6%) to Turgencin A. Chemical modification: Six cysteines has an unusual disulfide connectivity of Cys1-Cys6, Cys2-Cys5, and Cys3-Cys4 and an amidated C-terminus. Variation in peptide oxidation (M) has been observed. 67% Mox0, 29% Mox1, 4% Mox2. The first methionine is preferentially oxidized. Structure: NMR analysis reveals a possible C1-C6/C2-C5/C3-C4 disulfide pattern. It is likely that the peptide has some helical feture because both sample heterogeneity and peptide conformational dynamics caused a problem
Bio-Activity Profile
Antimicrobial Anticancer
Escherichia coli
12.5 μM
MIC
PaperIsolation and Characterization of Antimicrobial Peptides With Unusual Disulfide Connectivity From the Colonial Ascidian Synoicum turgens
RECORD: Rec_0037819 VERIFIED: YES
Provenance & Taxonomy
Synoicum turgens [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Bacillus subtilis ATCC 23857
1.6 μM
MIC
PMID31940927 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31940927/
RECORD: Rec_0049297 VERIFIED: YES
Provenance & Taxonomy
Synoicum turgens [Animal]
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
7-31, 11-27, 16-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Anticancer
Staphylococcus aureus ATCC 9144
100 μM
MIC
PMID31940927 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31940927/
RECORD: Rec_0072087 VERIFIED: YES
Provenance & Taxonomy
Synoicum turgens [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative Anti-Gram-positive Non-hemolytic
C. glutamicum (Gram-positive)
PMID31940927 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31940927/
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