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MYP_049801
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Basic Information
Human ApoE apolipoprotein derived peptide ApoEdpL-W
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Binding inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
18 amino acids
C148H202N48O19
Standard
Sequence
WRKWRKRWWWRKWRKRWW
Physicochemical Analysis
2957.50 Da
12.00
9.76
9.55
0.5420
-2.77
0.58
-0.82
109.31
0.00
0.4444
44000.00
44000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1159.82
0.53
49.0
29.0
91.0
215.0
16.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0261229 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HSV Binding inhibition
HSV-1 | NP-2/CD4/CCR5 cells
3.1 μM
IC50
Mammalian: 2.8 h; Yeast: 3 min; E. coli: 2 min
PaperApolipoprotein E-derived antimicrobial peptide analogues with altered membrane affinity and increased potency and breadth of activity. | Kelly BA, Neil SJ, McKnight A, Santos JM, Sinnis P, Jack ER, Middleton DA, Dobson CB. | FEBS J. 2007 Sep;274(17):4511-25. | DOI:10.1111/j.1742-4658.2007.05981.x | PMID:17681018 PMID17681018 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17681018/
RECORD: Rec_0289066 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 17681018 PMID17681018 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17681018/
RECORD: Rec_0302542 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Replication inhibition
HIV-1
10 μM
% inhibition
Mammalian: 2.8 h; Yeast: 3 min; E. coli: 2 min
PaperApolipoprotein E-derived antimicrobial peptide analogues with altered membrane affinity and increased potency and breadth of activity. | Kelly BA, Neil SJ, McKnight A, Santos JM, Sinnis P, Jack ER, Middleton DA, Dobson CB. | FEBS J. 2007 Sep;274(17):4511-25. | DOI:10.1111/j.1742-4658.2007.05981.x | PMID:17681018 PMID17681018 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17681018/
RECORD: Rec_0360724 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Antiviral
Staphylococcus aureus
PMID17681018 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17681018/
RECORD: Rec_0388240 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PaperPubMed PMID: 17681018 PMID17681018 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17681018/
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