Peptide Database

Peptide NameMP1S-Q12K

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length14 amino acids

Chemical FormulaC79H135N19O19

DescriptionStandard

        IDWKKLLDAAKKIL
    

Molecular Weight1655.03 Da

Isoelectric Point (pI)9.53

Net Charge (pH 7.0)1.76

Net Charge (pH 7.4) 1.55

Charge Density (pH 7.0) 0.1256

GRAVY Index0.04

Hydrophobic Moment 0.75

Boman Index0.01

Instability Index10.91

Aliphatic Index 153.57

Aromaticity 0.0714

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 636.09

LogP -0.84

H-bond Donors 22.0

H-bond Acceptors 21.0

Rotatable Bonds 59.0

Heavy Atoms 117.0

Ring Count 2.0

Amide Bonds 13.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0403051 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyPolybia-MP1

Tax ID32630

Structure & Mods

Confighydrocarbon-stapled side-chain cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Other ModsThe Ⓧ (position: 6 and 10) in sequence indicates (S)-α-methyl, α-pentenylglycine. Ⓧ (6) and Ⓧ (10) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetSalmonella typhimurium

Activity>100 μg/mL

MethodMIC

FIRST PREV 1 2 3 4

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