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MYP_049760
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Basic Information
MP1S-Q12K
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
14 amino acids
C79H135N19O19
Standard
Sequence
IDWKKLLDAAKKIL
Physicochemical Analysis
1655.03 Da
9.53
1.76
1.55
0.1256
0.04
0.75
0.01
10.91
153.57
0.0714
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
636.09
-0.84
22.0
21.0
59.0
117.0
2.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0154188 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The oct-4-enyl hydrocarbon staple between Leu6 and Ala10
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Bacillus subtilis
0.8 μM
MIC
PMID29075946 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29075946/
RECORD: Rec_0211413 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Polybia-MP1
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The Ⓧ (position: 6 and 10) in sequence indicates (S)-α-methyl, α-pentenylglycine. Ⓧ (6) and Ⓧ (10) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Hemolytic
human red blood cells
25 μM
Hemolysis
PaperHuy X Luong, Do-Hee Kim, Bong-Jin Lee, Young-Woo Kim. Antimicrobial activity and stability of stapled helices of polybia-MP1. Arch Pharm Res. 2017 Dec;40(12):1414-1419. Epub 2017 Oct 26. PMID29075946 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29075946/
RECORD: Rec_0257156 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The oct-4-enyl hydrocarbon staple between Leu6 and Ala10
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus epidermidis
50 μM
MIC
PMID29075946 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29075946/
RECORD: Rec_0287782 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The oct-4-enyl hydrocarbon staple between Leu6 and Ala10
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Hemolytic
human red blood cells
PMID29075946 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29075946/
RECORD: Rec_0302963 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Polybia-MP1
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The Ⓧ (position: 6 and 10) in sequence indicates (S)-α-methyl, α-pentenylglycine. Ⓧ (6) and Ⓧ (10) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli
>100 μg/mL
MIC
PaperHuy X Luong, Do-Hee Kim, Bong-Jin Lee, Young-Woo Kim. Antimicrobial activity and stability of stapled helices of polybia-MP1. Arch Pharm Res. 2017 Dec;40(12):1414-1419. Epub 2017 Oct 26. PMID29075946 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29075946/
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