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MYP_049679
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Basic Information
Drosophila diptericin
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antifungal
Antiviral
Standard
83 amino acids
C393H566N110O121S2
Standard
Sequence
DDMTMKPTPPPQYPLNLQGGGGGGSGDGFGFAVQGHQKVWTSDNGRHEIGLNGGYGQHLGGPYGNSEPSWKVGSTYTYRFPNF
Physicochemical Analysis
8831.49 Da
6.28
-0.98
-1.35
-0.0118
-0.88
0.41
0.04
26.96
35.18
0.1325
18450.00
18450.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
3656.83
-44.91
121.0
125.0
273.0
626.0
24.0
92.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0044335 VERIFIED: NO
Provenance & Taxonomy
Fruit fly [Animal]; Insecta [Animal]
33208; 50557
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Dip notation
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0075849 VERIFIED: YES
Provenance & Taxonomy
Drosophila melanogaster [Animal]
7227
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Induced via the IMD pathway. Glycosylation at Thr at the N-terminal Pro-rich domain. In all assays, activity appeared glycosylation independent. The C-terminal and N-terminal domains are both required for full activity. NMR and CD analysis revealed a lack of any defined structure even in the lipid environment (Winans KA et al., 1999; Cudic M et al., 1999). The peptide appeared to increase the inner and outer membrane permeability. Updated 10/5/2013
Bio-Activity Profile
Antimicrobial
PaperInsect immunity. Characterization of a Drosophila cDNA encoding a novel member of the diptericin family of immune peptides
RECORD: Rec_0099808 VERIFIED: YES
Provenance & Taxonomy
Drosophila melanogaster [Animal]
Diptericin
7227
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
PaperJ Biol Chem. 1990 Dec 25;265(36):22493-8 | http://www.ncbi.nlm.nih.gov/pubmed/2125051 PMID2125051 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2125051/
RECORD: Rec_0204567 VERIFIED: YES
Provenance & Taxonomy
Drosophila melanogaster [Animal]
7227
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antiviral
PaperPubMed PMID: 2125051 PMID2125051 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2125051/
RECORD: Rec_0254274 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
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