Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length472 amino acids

Chemical FormulaC2311H3716N596O654S20

DescriptionStandard

        MVTSGRMSPWCLLTLLTLVPLTLSSNAGVKVKLTQKGLEYARQIGMTTLQQKLKTIKVPDLSGTEKVAPIGKVKYTLSGMQITSLGLPKSQMGMVPGTGVSLAIGNAFLSLHGNWKVRYLHFIKDSGSFDLAVKDLTINTNIALKSDETGRPAVNTVSCTSNVGSASIKFHGGASAYIDKALRSALQKQICPLVSDAISELNPHLKTLNVLAPVDKYAEIEYSMVASPVVSKAFVDFGLKGEFYNIGRHKEPPFSPPVFGLPPQVNNMLYIGVSSFTANSASFVYNNAGAFNLFITDDMIPPSSPIRLNTRTFGAFIPQLAKEYPGLMMKLLVKTTRQPIISFQVNNVTLQASGTVTAYAIQPNTTLAPLFILNMETSVSAHIYVTGVKLAGSVILNRMSMSLGASYVGPFQVKSLDNIFLMVLKVAVLPKINAHLQKGYPLPAIGKMSLVNTQLQVLKDYMLIGTDVSFRG
    

Molecular Weight50955.12 Da

Isoelectric Point (pI)9.69

Net Charge (pH 7.0)19.08

Net Charge (pH 7.4) 18.37

Charge Density (pH 7.0) 0.0404

GRAVY Index0.21

Hydrophobic Moment 0.70

Boman Index0.17

Instability Index37.72

Aliphatic Index 101.80

Aromaticity 0.0784

Extinction Coeff. Reduced 33350.00

Extinction Coeff. Oxidized 33475.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0425242 VERIFIED: NO

Provenance & Taxonomy

OrganismClupea harengus [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria