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MYP_049593
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Basic Information
HBD2
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Standard
37 amino acids
C172H282N50O46S6
Standard
Sequence
DPVTCLKSGAICHPVFCPRRYKQIGTCGLPGTKCCKP
Physicochemical Analysis
3978.78 Da
9.13
4.78
4.43
0.1293
-0.11
0.52
-0.00
48.07
60.54
0.0541
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1505.07
-15.92
57.0
58.0
123.0
274.0
8.0
37.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0014781 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
BK virus (Virus entry); Vero
45 %
Flow cytometry
PaperHuman alpha-defensins inhibit BK virus infection by aggregating virions and blocking binding to host cells. | Dugan AS, Maginnis MS, Jordan JA, Gasparovic ML, Manley K, Page R, Williams G, Porter E, O'Hara BA, Atwood WJ. | J Biol Chem. 2008 | PMID:18782756 PMID18782756 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18782756/
RECORD: Rec_0248224 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 18.9%, E 29.7%, T 24.3%, C 27.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/