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MYP_049588
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Basic Information
Temporin-1Sa [L2,9A;V6A]
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
13 amino acids
C59H92N14O15S
Standard
Sequence
FASGIAGMAGKLF
Physicochemical Analysis
1269.51 Da
8.75
0.76
0.55
0.0584
1.18
0.36
0.54
-0.87
83.08
0.1538
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
458.77
-3.38
16.0
17.0
41.0
89.0
2.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0044457 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Temporin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
HepG2
600 μM
IC50
PaperPubMed PMID: 28319176 PMID28319176 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28319176/
RECORD: Rec_0061412 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Temporin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
Rat erythrocytes: >200μM
50 %
Hemolysis
PaperPubMed PMID: 28319176 PMID28319176 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28319176/
RECORD: Rec_0097835 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Anticancer
RECORD: Rec_0175171 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Temporin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PaperPubMed PMID: 28319176 PMID28319176 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28319176/
RECORD: Rec_0217252 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Listeria ivanovii
200 μM
MBC
PMID30813478 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30813478/
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