Peptide Database

Peptide NameSLAY-screened peptide P5644

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC96H157N23O31S

DescriptionStandard

        LPTHAIITLTTATLECNSYV
    

Molecular Weight2161.47 Da

Isoelectric Point (pI)5.24

Net Charge (pH 7.0)-1.16

Net Charge (pH 7.4) -1.43

Charge Density (pH 7.0) -0.0580

GRAVY Index0.67

Hydrophobic Moment 0.22

Boman Index0.33

Instability Index41.10

Aliphatic Index 122.00

Aromaticity 0.0500

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 858.11

LogP -8.48

H-bond Donors 31.0

H-bond Acceptors 32.0

Rotatable Bonds 65.0

Heavy Atoms 151.0

Ring Count 3.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0420441 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/