Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length497 amino acids

Chemical FormulaC2482H3974N624O707S18

DescriptionStandard

        MMQCSQKYEHFADDLVLYLPEVKMYLRCWLALLLALVPATLSTKPGVKIKLTEKGLEYGKSQSIAALQQKLKSIKIPDISGSGKVLHIGVVKYSLSNMQIVNIGLPKTEVDLVPGSAVRLSISNTFISLHGNWKIKYLHYMKNSGSFDLNVNKLTITTDIAIKSDETGRPAVSTVSCGATVGSLTIKFHGGASWLYNLIKDVLENKARKELQKQICPLVTEAVSDLNPQLKTLNVLAKVDQYAEIEYSMVSSPTISNSSVELSLKGEFYNIGKHQEPPFSPADFSLPPQIDRMLYIGVSVFTANSAAFVYNKAGALSLYITDDMIPQGSPFRLNTKTFGIFIPQIAKQFPGLMMKLLVKTVKDPIITFQPNNVTVQATATVTAYAIQPNATLAPLFVLNLETSVSAHVFVSGMSLAGDVALNKINLTLATSYVGDFQFKPLDNMFQMVLKVVVIPKLNAQLGKGHPLPTFGKTKLVNTQLQVLKDYMLIGTDVQFTG
    

Molecular Weight54445.03 Da

Isoelectric Point (pI)9.23

Net Charge (pH 7.0)12.16

Net Charge (pH 7.4) 11.36

Charge Density (pH 7.0) 0.0245

GRAVY Index0.14

Hydrophobic Moment 0.63

Boman Index0.16

Instability Index30.76

Aliphatic Index 104.71

Aromaticity 0.0825

Extinction Coeff. Reduced 41830.00

Extinction Coeff. Oxidized 42080.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0364748 VERIFIED: NO

Provenance & Taxonomy

OrganismStegastes partitus [Bacterium]

FamilyBPI

Tax ID144197

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence