Peptide Database

Peptide NamePigment-dispersing hormone

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC83H142N22O28S

DescriptionStandard

        NSELINSILGLPKVMNDA
    

Molecular Weight1928.21 Da

Isoelectric Point (pI)4.37

Net Charge (pH 7.0)-1.24

Net Charge (pH 7.4) -1.44

Charge Density (pH 7.0) -0.0687

GRAVY Index0.18

Hydrophobic Moment 0.49

Boman Index0.17

Instability Index36.83

Aliphatic Index 130.00

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 819.58

LogP -8.48

H-bond Donors 26.0

H-bond Acceptors 28.0

Rotatable Bonds 65.0

Heavy Atoms 134.0

Ring Count 1.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0210833 VERIFIED: YES

Provenance & Taxonomy

OrganismHomarus americanus [Animal]

FamilyArthropod PDH

Tax ID6706

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Neuropeptide Circadian regulation Chromatophore regulation

RECORD: Rec_0235837 VERIFIED: YES

Provenance & Taxonomy

OrganismCallinectes sapidus [Animal]

FamilyArthropod PDH

Tax ID6763

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Neuropeptide Circadian regulation Chromatophore regulation

PaperDiscovery and characterization of the Crustacean hyperglycemic hormone precursor related peptides (CPRP) and orcokinin neuropeptides in the sinus glands of the blue crab Callinectes sapidus using multiple tandem mass spectrometry techniques PMID21740068 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21740068/

RECORD: Rec_0256287 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/

RECORD: Rec_0263456 VERIFIED: NO

Provenance & Taxonomy

OrganismUca pugilator [Animal]; Carcinus maenas [Animal]; Cancer productus [Animal]; Cancer borealis [Animal]; Homarus americanus [Animal]; Ocypode ceratophthalma [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Hormone

RECORD: Rec_0269160 VERIFIED: YES

Provenance & Taxonomy

OrganismLeptuca pugilator [Animal]

FamilyPigment-dispersing hormone

Tax ID6772

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator

Targetpigment chromatophore cells

Half-LifeMammalian: 1.4 hour; Yeast: 3 min; E. coli: >10 hour

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