Peptide Database

Peptide NameK8I (mutant of Def-DAA defensin)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Standard StatusStandard

Sequence Length39 amino acids

Chemical FormulaC186H289N61O51S6

DescriptionStandard

        ATCDLASIWNWNHTLCAAHCIARRYRGGYCNSKAVCVCR
    

Molecular Weight4388.05 Da

Isoelectric Point (pI)8.94

Net Charge (pH 7.0)3.91

Net Charge (pH 7.4) 3.53

Charge Density (pH 7.0) 0.1002

GRAVY Index0.01

Hydrophobic Moment 0.52

Boman Index-0.01

Instability Index19.54

Aliphatic Index 70.26

Aromaticity 0.1026

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 14355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1819.63

LogP -20.42

H-bond Donors 73.0

H-bond Acceptors 63.0

Rotatable Bonds 137.0

Heavy Atoms 304.0

Ring Count 8.0

Amide Bonds 41.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0032664 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyDefensin

Tax ID32630

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive

TargetStaphylococcus aureus strain 21

Activity2 μg/mL

MethodIC90

RECORD: Rec_0346769 VERIFIED: YES