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MYP_049139
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Basic Information
Mutacin, or Mutacin B-Ny266
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
22 amino acids
C107H150N26O31S4
Standard
Sequence
FKSWSFCTPGCAKTGSFNSYCC
Physicochemical Analysis
2424.75 Da
8.52
1.72
1.45
0.0781
-0.01
0.17
0.13
13.67
4.55
0.2273
6990.00
7240.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
918.16
-11.65
37.0
37.0
72.0
168.0
7.0
22.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0007962 VERIFIED: YES
Provenance & Taxonomy
Streptococcus mutans [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Enterococcus spp
12.8
MIC
PaperPurification and structure of mutacin B-Ny266: a new lantibiotic produced by Streptococcus mutans
RECORD: Rec_0013583 VERIFIED: YES
Provenance & Taxonomy
Streptococcus mutans [Bacterium]
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0021593 VERIFIED: NO
Provenance & Taxonomy
Streptococcus mutans [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperPatent US 2023/0416797 A1 Evidence URLhttps://patents.google.com/patent/US20230416797A1/en PatentUS 2023/0416797 A1
RECORD: Rec_0046779 VERIFIED: YES
Provenance & Taxonomy
Streptococcus mutans [Bacterium]
Lantibiotic
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Bacteriocin Lantibiotic Anti-Gram-positive Non-hemolytic
Gram Positive Bacteria
PMID9237644 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9237644/
RECORD: Rec_0091705 VERIFIED: YES
Provenance & Taxonomy
Streptococcus mutans [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Neisseria spp
1.6
MIC
PaperPurification and structure of mutacin B-Ny266: a new lantibiotic produced by Streptococcus mutans
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