Peptide Database

Peptide NameSLAY-screened peptide P469

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length8 amino acids

Chemical FormulaC39H60N10O17

DescriptionStandard

        TQNYLSDT
    

Molecular Weight940.95 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-1.60

Net Charge (pH 7.4) -1.79

Charge Density (pH 7.0) -0.2002

GRAVY Index-1.27

Hydrophobic Moment 0.30

Boman Index-0.19

Instability Index-19.46

Aliphatic Index 48.75

Aromaticity 0.1250

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 471.42

LogP -6.84

H-bond Donors 16.0

H-bond Acceptors 16.0

Rotatable Bonds 29.0

Heavy Atoms 66.0

Ring Count 1.0

Amide Bonds 9.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0114824 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/