Peptide Database

Peptide NameACE inhibitory peptide

Function Ontology

Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC70H128N30O20S

DescriptionStandard

        RNEQMGAGRLGRLRK
    

Molecular Weight1742.02 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)3.76

Net Charge (pH 7.4) 3.56

Charge Density (pH 7.0) 0.2508

GRAVY Index-1.49

Hydrophobic Moment 0.43

Boman Index-0.61

Instability Index37.58

Aliphatic Index 58.67

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 867.82

LogP -10.87

H-bond Donors 32.0

H-bond Acceptors 25.0

Rotatable Bonds 64.0

Heavy Atoms 121.0

Ring Count 0.0

Amide Bonds 16.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0139242 VERIFIED: YES

Provenance & Taxonomy

OrganismPhaseolus vulgaris [Plant]

FamilyBioactive peptides

Tax ID3885

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

ACE inhibitory Antihypertensive

TargetAngiotensin-converting enzyme

Activity0.095 μM

MethodIC50

RECORD: Rec_0202524 VERIFIED: YES

Provenance & Taxonomy

OrganismPhaseolus vulgaris [Plant]

Tax ID3885.0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antihypertensive ACE inhibitory

TargetAngiotensin-converting enzyme (ACE)

PaperMojica L., Chen K., de Mejia E.G.. Impact of Commercial Precooking of Common Bean (Phaseolus vulgaris) on the Generation of Peptides, After Pepsin-Pancreatin Hydrolysis, Capable to Inhibit Dipeptidyl Peptidase-IV. Journal of Food Science, 80, 188-198, DOI: 10.1111/1750-3841.12726. PMID25495131 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25495131/