Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length286 amino acids

Chemical FormulaC1418H2250N396O400S12

DescriptionStandard

        MMARPYYMVVALLLLAEFTRFGEGTPNPGFMVRITGKGLEYAHQYGVATLKNDLSTIKLPDLSGSYGIGWLGSVNYVFSGMRIHHFLLRNSQLSLHPRQGIKASLSNNHVSVSGNWKVKKSFITLHGTFDLSVDGMSVLVSLNLDKDQSGRPTVSVTHCHNSIGHVSIEISGHISWILNLFHERIENNVKNILEQKICKMVKESAASRLEPYLRTLPVTSMIDQIAGIDYRLVGAPQVTFQGLDTPFKVRGCRERALEPGTGRNPVLPLRVGFSSPPDHLLVSPCP
    

Molecular Weight31630.23 Da

Isoelectric Point (pI)9.39

Net Charge (pH 7.0)8.53

Net Charge (pH 7.4) 7.59

Charge Density (pH 7.0) 0.0298

GRAVY Index-0.05

Hydrophobic Moment 0.71

Boman Index0.08

Instability Index34.87

Aliphatic Index 96.36

Aromaticity 0.0769

Extinction Coeff. Reduced 28420.00

Extinction Coeff. Oxidized 28670.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0089946 VERIFIED: NO

Provenance & Taxonomy

OrganismBos indicus x Bos taurus [Animal]

FamilyBPI

Tax ID30522

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence