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MYP_048827
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Basic Information
Melittin
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxin
Standard
26 amino acids
C131H227N37O33
Standard
Sequence
GIGAILKVLSTGLPALISWIKRKRQE
Physicochemical Analysis
2848.43 Da
11.10
3.77
3.55
0.1448
0.28
0.57
0.11
52.14
138.85
0.0385
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1140.76
-7.88
41.0
37.0
98.0
201.0
3.0
26.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0089391 VERIFIED: NO
Provenance & Taxonomy
Apis dorsata [Animal]
Melittin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Neuropeptide
RECORD: Rec_0162017 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 30.8%, E 0.0%, T 53.8%, C 15.4% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Toxic Cytotoxic
PaperIn silico approach for predicting toxicity of peptides and proteins PMID24058508 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24058508/
RECORD: Rec_0216387 VERIFIED: YES
Provenance & Taxonomy
Apis dorsata [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0401963 VERIFIED: YES
Provenance & Taxonomy
Apis dorsata [Animal]
Melittin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Cytolytic Toxin Hemolytic
PMID1093875 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1093875/
RECORD: Rec_0402340 VERIFIED: NO
Provenance & Taxonomy
Apis dorsata [Animal]
Melittin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Evidence URLhttps://camp.bicnirrh.res.in/seqDisp.php?id=CAMPSQ6375