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MYP_048776
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Basic Information
PGLa-MW1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
21 amino acids
C88H160N24O25S
Standard
Sequence
GMASKAGSVLGKITKIALGAL
Physicochemical Analysis
1986.42 Da
10.30
2.76
2.55
0.1313
0.86
0.56
0.34
-0.77
125.71
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
784.07
-7.91
28.0
29.0
70.0
138.0
0.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0238886 VERIFIED: YES
Provenance & Taxonomy
Xenopus muelleri West [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
human erythrocytes
>200 μM
Hemolysis
PMID21664395 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21664395/
RECORD: Rec_0241147 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
PGLa
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial
Human erythrocytes
200 μM
LC50
Paperhttps://pubmed.ncbi.nlm.nih.gov/21664395/ PMID21664395 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21664395/
RECORD: Rec_0289653 VERIFIED: YES
Provenance & Taxonomy
Xenopus borealis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0289654 VERIFIED: YES
Provenance & Taxonomy
Xenopus muelleri [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Staphylococcus aureus
100 μM
MIC
PaperPeptidomic analysis of skin secretions demonstrates that the allopatric populations of Xenopus muelleri (Pipidae) are not conspecific
RECORD: Rec_0309286 VERIFIED: YES
Provenance & Taxonomy
Xenopus muelleri [Animal]
PGLa
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antifungal
PaperM. Mechkarska et al. / Peptides 32 (2011) 1502-1508. Peptidomic analysis of skin secretions demonstrates that the allopatric populations of Xenopus muelleri (Pipidae) are not conspecific
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