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MYP_048772
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Basic Information
C-9 (analog of P18)
Anticancer
Anticancer ▸ Antitumor
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
13 amino acids
C88H142N20O14
Standard
Sequence
KWKLFKKIPLKKF
Physicochemical Analysis
1704.19 Da
10.70
5.75
5.54
0.4426
-0.63
0.37
-0.17
-24.14
90.00
0.2308
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
575.64
1.84
20.0
20.0
60.0
122.0
5.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0013640 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Anticancer
Proteus vulgaris
3.125 μM
MIC
PaperAntibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs. J Pept Res. 2001 Dec;58(6):504-14. doi: 10.1034/j.1399-3011.2001.00934.x. PMID: 12005420. PMID12005420 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12005420/
RECORD: Rec_0035356 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
P18 analog
32630
Structure & Mods
linear peptide [Linear]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antitumor
Mammalian 1.3 h; Yeast 3 min; E. coli 2 min
PaperAntibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs PMID12005420 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12005420/
RECORD: Rec_0056145 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus KCTC 1621
12.5 μM
MIC
PMID12005420 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12005420/
RECORD: Rec_0064969 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 38.5%, C 61.5% [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Antibacterial Toxic Antimicrobial Hemolytic
PaperHemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides PMID24174543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24174543/
RECORD: Rec_0088675 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Anticancer
Escherichia coli KCTC 1682
12.5 μM
MIC
PaperAntibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs. J Pept Res. 2001 Dec;58(6):504-14. doi: 10.1034/j.1399-3011.2001.00934.x. PMID: 12005420. PMID12005420 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12005420/
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