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MYP_048761
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Basic Information
pentapeptide
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Delivery / Targeting ▸ Targeting ligand ▸ Targeting
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
5 amino acids
C27H43N9O8
Standard
Sequence
RGDFK
Physicochemical Analysis
621.69 Da
8.75
0.76
0.56
0.1520
-1.90
0.52
-0.65
-54.12
0.00
0.2000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
304.94
-2.92
11.0
9.0
21.0
44.0
1.0
4.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0005886 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Source entry describes small-molecule/peptide conjugation at one terminus; exact terminus not explicitly assigned in source metadata
Conjugate type: sulfonamide; Conjugated small molecule: 2,3-dihydro-2,2,4,6,7-pentamethyl-5-benzofuransulfonamide
Bio-Activity Profile
-
PaperSolid-phase-based synthesis of ureidopyrimidinone-peptide conjugates for supramolecular biomaterials. Synlett. 2015 Evidence URLhttps://doi.org/10.1055/s-0035-1560520
RECORD: Rec_0049834 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
cRGD
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cycliclization
Cyclization
Bio-Activity Profile
Cell-penetrating peptide Cargo delivery
PMID25108152 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25108152/
RECORD: Rec_0050527 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Anticancer
RECORD: Rec_0077150 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
all-D amino-acid peptide [D]
Source entry describes small-molecule/peptide conjugation at one terminus; exact terminus not explicitly assigned in source metadata
Conjugated small molecule: O-¦Â-D-Galactopyranosyl-(1¡ú3)-O-¦Â-D-galactopyranosyl-(1¡ú4)-¦Â-D-glucopyranose
Bio-Activity Profile
Anticancer Targeting
PaperBifunctional ligands that target cells displaying the ¦Áv¦Â3 integrin. ChemBioChem. 2007 Evidence URLhttps://doi.org/10.1002/cbic.200600339
RECORD: Rec_0084325 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Source entry describes small-molecule/peptide conjugation at one terminus; exact terminus not explicitly assigned in source metadata
Conjugate type: sulfonamide; Conjugated small molecule: ureidopyrimidinone
Bio-Activity Profile
-
PaperSolid-phase-based synthesis of ureidopyrimidinone-peptide conjugates for supramolecular biomaterials. Synlett. 2015 Evidence URLhttps://doi.org/10.1055/s-0035-1560520
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