Peptide Database

Peptide NameUnnamed

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor

Standard StatusStandard

Sequence Length36 amino acids

Chemical FormulaC203H295N53O64

DescriptionStandard

        HSLIEESQNQQEKNEQELLELDKWASLWNWFNITNW
    

Molecular Weight4501.83 Da

Isoelectric Point (pI)4.30

Net Charge (pH 7.0)-5.14

Net Charge (pH 7.4) -5.40

Charge Density (pH 7.0) -0.1427

GRAVY Index-1.14

Hydrophobic Moment 0.46

Boman Index-0.10

Instability Index66.73

Aliphatic Index 78.61

Aromaticity 0.1389

Extinction Coeff. Reduced 22000.00

Extinction Coeff. Oxidized 22000.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1955.53

LogP -16.47

H-bond Donors 64.0

H-bond Acceptors 60.0

Rotatable Bonds 151.0

Heavy Atoms 320.0

Ring Count 10.0

Amide Bonds 44.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0392133 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-HIV Fusion inhibition

TargetHuman immunodeficiency virus (HIV) | MT-2 cells

Activity2.185±0.015 μM

MethodIC50

Half-LifeMammalian: 3.5 h; Yeast: 10 min; E. coli: >10 h

PaperHIV gp41 C-terminal heptad repeat contains multifunctional domains. Relation to mechanisms of action of anti-HIV peptides | Liu S, Jing W, Cheung B, Lu H, Sun J, Yan X, Niu J, Farmar J, Wu S, Jiang S. | J Biol Chem. 2007 Mar 30;282(13):9612-9620. | DOI:10.1074/jbc.M609148200 | PMID:17276993 PMID17276993 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17276993/

RECORD: Rec_0404473 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Fusion inhibitor

MethodQualitative inhibition

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