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MYP_048678
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Basic Information
Unnamed
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Standard
36 amino acids
C203H295N53O64
Standard
Sequence
HSLIEESQNQQEKNEQELLELDKWASLWNWFNITNW
Physicochemical Analysis
4501.83 Da
4.30
-5.14
-5.40
-0.1427
-1.14
0.46
-0.10
66.73
78.61
0.1389
22000.00
22000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1955.53
-16.47
64.0
60.0
151.0
320.0
10.0
44.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0005919 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperHIPdb: a database of experimentally validated HIV inhibiting peptides PMID23359817 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23359817/
RECORD: Rec_0076278 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 17276993 PMID17276993 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17276993/
RECORD: Rec_0094285 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Fusion inhibitor
CEM
0.139 μg/mL
IC50
PaperMethods and compositions for treatment of HIV-1 infection using antiviral compounds in simultaneous or sequential combinations PatentUS6861059
RECORD: Rec_0219858 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
human immunodeficiency virus (HIV):inhibition of cell-cell fusion in MT-2 cells
0.002 μM
IC50
PaperPubMed PMID: 17276993 PMID17276993 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17276993/
RECORD: Rec_0368826 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV
Human immunodeficiency virus (HIV)
2.858±0.006 μM
IC90
Mammalian: 3.5 h; Yeast: 10 min; E. coli: >10 h
PaperHIV gp41 C-terminal heptad repeat contains multifunctional domains. Relation to mechanisms of action of anti-HIV peptides | Liu S, Jing W, Cheung B, Lu H, Sun J, Yan X, Niu J, Farmar J, Wu S, Jiang S. | J Biol Chem. 2007 Mar 30;282(13):9612-9620. | DOI:10.1074/jbc.M609148200 | PMID:17276993 PMID17276993 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17276993/
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