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MYP_048666
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Basic Information
HPIV3 F HRC derived peptide(449-484)[L451N,I484D]
Antimicrobial
Antiviral
Antiviral ▸ Anti-Influenza virus
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Standard
36 amino acids
C177H291N51O64
Standard
Sequence
VANDPIDISIELNKAKSDLEESKEWIRRSNQKLDSD
Physicochemical Analysis
4157.51 Da
4.65
-3.25
-3.48
-0.0903
-1.09
0.66
-0.30
67.75
89.44
0.0278
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1925.91
-21.66
65.0
61.0
147.0
292.0
3.0
39.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0260736 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-Influenza virus Fusion inhibition
human parainfluenza virus 3 (HPIV3) | HeLa cells
1.1 μM
IC50
Mammalian: 100 h; Yeast: >20 h; E. coli: >10 h
PaperInhibition of hendra virus fusion. | Porotto M, Doctor L, Carta P, Fornabaio M, Greengard O, Kellogg GE, Moscona A. | J Virol. 2006 Oct;80(19):9837-49. | DOI:10.1128/JVI.00736-06 | PMID:16973588 PMID16973588 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16973588/
RECORD: Rec_0263031 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
inhibition of fusion in HeLa cells
1 μM
IC50
PaperPubMed PMID: 16973588 PMID16973588 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16973588/
RECORD: Rec_0287134 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
inhibition of fusion in HeLa cells
0.75 μM
IC50
PaperPubMed PMID: 16973588 PMID16973588 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16973588/
RECORD: Rec_0309470 VERIFIED: YES
Provenance & Taxonomy
Hendra henipavirus [Virus]
Virus-derived peptide
3052223;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Fusion inhibitor
Hendra virus (Fusion); HeLa
10 μM
Luminescence fusion assay
PaperInhibition of hendra virus fusion. | Porotto M, Doctor L, Carta P, Fornabaio M, Greengard O, Kellogg GE, Moscona A. | J Virol. 2006 | PMID:16973588 PMID16973588 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16973588/
RECORD: Rec_0385282 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
human parainfluenza virus 3 (HPIV3):inhibition of virus infection in HeLa cells
1.1 μM
IC50
PaperPubMed PMID: 16973588 PMID16973588 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16973588/
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